Cryomicroscopy

Cryomicroscopy is a powerful tool for obtaining the structure of biological macromolecules with atomic resolution; this includes the architecture of cells, viruses, and protein complexes. Orion will have state-of-the-art transmission electron cryomicroscopes and detectors, as well as the full infrastructure necessary to prepare samples, making it possible to conduct in situ analysis of pathogen structures. These analyses will utilize electron cryotomography, a technique that can reveal details of cell superstructures as well as mechanisms of infection.