{"id":68747,"date":"2013-07-15T13:43:42","date_gmt":"2013-07-15T16:43:42","guid":{"rendered":"https:\/\/cnpem.br\/brazil-and-france-join-forces-to-search-the-biology-of-bacteria\/"},"modified":"2013-07-15T13:43:42","modified_gmt":"2013-07-15T16:43:42","slug":"brazil-and-france-join-forces-to-search-the-biology-of-bacteria","status":"publish","type":"post","link":"https:\/\/cnpem.br\/en\/brazil-and-france-join-forces-to-search-the-biology-of-bacteria\/","title":{"rendered":"Brazil and France join forces to search the biology of bacteria"},"content":{"rendered":"


\n\"\"<\/a><\/p>\n

Communication of LNBio \u2013 15th July 2013<\/p>\n

Available only in Portuguese<\/p>\n

Brasil e Fran\u00e7a se associam para pesquisar a biologia de bact\u00e9rias<\/strong><\/p>\n

Laborat\u00f3rio Nacional de Bioci\u00eancias (LNBio) e Instituto de Biologia Estrutural (IBS) se unem para\u00a0 expandir conhecimentos sobre infec\u00e7\u00f5es bacterianas<\/em><\/p>\n

 <\/p>\n

O Laborat\u00f3rio Nacional de Bioci\u00eancias (LNBio) foi nomeado na \u00faltima sexta-feira, 12 de julho de 2013, Laborat\u00f3rio Internacional Associado (LIA) do Instituto de Biologia Estrutural (IBS) de Grenoble, na Fran\u00e7a. A assinatura do acordo foi realizada no Campus<\/em>\u00a0do Centro Nacional de Pesquisa em Energia e Materiais (CNPEM) em Campinas \u2013 SP e formalizou a coopera\u00e7\u00e3o cient\u00edfica entre o LNBio e o IBS nas pesquisas sobre parede bacteriana.<\/p>\n

O conhecimento das estruturas moleculares e das fun\u00e7\u00f5es das prote\u00ednas que formam a parede bacteriana \u00e9 fundamental para compreender como bact\u00e9rias infectam as c\u00e9lulas e desenvolvem resist\u00eancia aos antibi\u00f3ticos. Os resultados dessas pesquisas s\u00e3o importantes para a cria\u00e7\u00e3o de novos medicamentos e vacinas.<\/p>\n

O LNBio se tornou um Laborat\u00f3rio Internacional Associado (LIA) do IBS, estrat\u00e9gia de coopera\u00e7\u00e3o internacional promovida pelo Centro Nacional de Pesquisa Cient\u00edfica (CNRS), \u00f3rg\u00e3o do governo franc\u00eas. Por meio desses, chamados popularmente de \u00b4laborat\u00f3rios sem paredes\u00b4, os institutos de pesquisa da Fran\u00e7a desenvolvem projetos em parceria com institui\u00e7\u00f5es estrangeiras e compartilham disposi\u00e7\u00f5es relacionadas \u00e0 propriedade intelectual, recursos humanos e financeiros.<\/p>\n

A parceria entre o LNBio e o IBS nos estudos sobre a biologia estrutural de bact\u00e9rias come\u00e7ou em 2012, com a volta da pesquisadora Andrea Dessen ao Brasil. Fora do pa\u00eds h\u00e1 mais de 25 anos, Dessen foi a primeira selecionada pelo \u201cPrograma-piloto S\u00e3o Paulo Excellence Chairs\u201d (Spec), uma iniciativa da Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo (FAPESP) que promove colabora\u00e7\u00f5es entre institui\u00e7\u00f5es paulistas e pesquisadores brasileiros de alto n\u00edvel radicados no exterior. Andrea lidera um grupo de patogenia bacteriana no IBS e, por meio do SPEC, passou a coordenar pesquisas nessa \u00e1rea no LNBio h\u00e1 cerca de um ano e meio.<\/p>\n

A formaliza\u00e7\u00e3o dessa parceria contou com a presen\u00e7a, pelo lado franc\u00eas, de Gilles Bloch, diretor do Departamento das Ci\u00eancias da Vida da Comiss\u00e3o Francesa de Energias Alternativas e Energia At\u00f4mica (CEA); Renaud Blaise, diretor\u00a0de Rela\u00e7\u00f5es Internacionais do CEA; Serge Perez, conselheiro do Servi\u00e7o Nuclear da Embaixada da Fran\u00e7a em Bras\u00edlia; Jean-Pierre Briot,\u00a0representante do CNRS no Brasil; Yassine Lakhnech, vice-presidente de Pesquisa da Universidade Joseph Fourier; G\u00e9rard\u00a0Chuzel,\u00a0Adido\u00a0para a\u00a0Ci\u00eancia e a Tecnologia\u00a0do\u00a0Consulado\u00a0Geral da Fran\u00e7a em S\u00e3o Paulo. O CNRS, a CEA e o Universidade Joseph Fourier s\u00e3o \u00f3rg\u00e3os p\u00fablicos franceses respons\u00e1veis pela tutela do IBS.<\/p>\n

Durante a cerim\u00f4nia que formalizou o acordo, Giles Bloch ressaltou o forte progresso do Brasil no desenvolvimento de ci\u00eancia e tecnologia desde a sua \u00faltima visita ao Pa\u00eds, h\u00e1 cinco anos. Bloch comentou ainda a import\u00e2ncia da parceria entre LNBio e IBS. \u00abEsse laborat\u00f3rio mostra bem o que \u00e9 a biologia molecular, onde voc\u00ea parte do estudo de uma estrutura molecular, analisa a sua fun\u00e7\u00e3o e chega a poss\u00edveis aplica\u00e7\u00f5es\u00bb, explica Bloch.<\/p>\n

Do lado brasileiro, acompanharam a cerim\u00f4nia: Carlos Henrique de Brito Cruz, diretor cient\u00edfico da FAPESP; Andrea Dessen, l\u00edder da parte francesa do LIA e pesquisadora do LNBio e do IBS; Kleber Franchini, l\u00edder do lado brasileiro do LIA e diretor do LNBio e o Carlos Alberto Arag\u00e3o, diretor-geral do CNPEM.<\/p>\n

As pesquisas sobre a biologia bacteriana<\/strong><\/p>\n

As pesquisas realizadas no LNBio estudam uma estrutura presente na superf\u00edcie das c\u00e9lulas bacterianas, semelhante \u00e0 uma agulha, utilizada para injetar toxinas dentro das c\u00e9lulas humanas saud\u00e1veis, com a inten\u00e7\u00e3o de mat\u00e1-las. O trabalho consiste em desvendar como essa \u00b4agulha\u00b4 \u00e9 sintetizada pela bact\u00e9ria, assim como as toxinas e seus efeitos envolvidos no processo.<\/p>\n

Esse \u00e9 um sistema de infec\u00e7\u00e3o agressivo, tanto que algumas toxinas destroem as c\u00e9lulas em cerca de 30 minutos. A bact\u00e9ria que causa peste bub\u00f4nica e a que infecta pessoas que t\u00eam fibrose c\u00edstica s\u00e3o exemplos que utilizam esse mecanismo. Compreender como esse sistema \u00e9 gerado e pode ser controlado \u00e9 de grande valia no desenvolvimento de antibi\u00f3ticos e vacinas que possam controlar esse tipo de infec\u00e7\u00e3o no futuro.<\/p>\n

Uma segunda linha de pesquisa investiga como a parede bacteriana \u00e9 formada e as enzimas envolvidas nesse processo. Sabe-se que a penicilina, por exemplo, bloqueia parte dessas prote\u00ednas, mas muitas bact\u00e9rias j\u00e1 desenvolveram resist\u00eancia a esse antibi\u00f3tico. A ideia \u00e9 estudar tais enzimas, tendo em vista o desenvolvimento de novas mol\u00e9culas antibi\u00f3ticas. No LNBio esses ensaios s\u00e3o conduzidos principalmente com bact\u00e9rias do tipo Pseudomonas, conhecidas por causarem infec\u00e7\u00e3o hospitalar.<\/p>\n

Tais projetos combinam t\u00e9cnicas de cristalografia com raios X, bioqu\u00edmica, biologia molecular e microscopia eletr\u00f4nica e s\u00e3o desenvolvidos em parceria com a Universidade de Oxford; Universidade de Ljubljana, na Eslov\u00eania; Universidade de Utrecht, na Holanda e Instituto Pasteur, de Paris. Essas colabora\u00e7\u00f5es, firmadas antes da formaliza\u00e7\u00e3o do LIA e previstas no SPEC, ser\u00e3o mantidas no novo acordo.<\/p>\n","protected":false},"excerpt":{"rendered":"

Communication of LNBio \u2013 15th July 2013 Available only in Portuguese Brasil e Fran\u00e7a se associam para pesquisar a biologia de bact\u00e9rias Laborat\u00f3rio Nacional de Bioci\u00eancias (LNBio) e Instituto de…<\/p>\n","protected":false},"author":17,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[1452,1458,1480],"tags":[],"class_list":["post-68747","post","type-post","status-publish","format-standard","hentry","category-clipping-cnpem-en","category-releases-cnpem-en-2","category-releases-lnbio-en","category-1452","category-1458","category-1480","description-off"],"acf":[],"yoast_head":"\nBrazil and France join forces to search the biology of bacteria - 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