{"id":3953,"date":"2012-03-15T12:19:23","date_gmt":"2012-03-15T15:19:23","guid":{"rendered":"https:\/\/www.cnpem.staging.wpengine.com\/?p=3953"},"modified":"2026-03-03T10:13:13","modified_gmt":"2026-03-03T13:13:13","slug":"camundongo-recebe-sistema-imune-humano","status":"publish","type":"post","link":"https:\/\/cnpem.br\/en\/camundongo-recebe-sistema-imune-humano\/","title":{"rendered":"Camundongo recebe sistema imune humano"},"content":{"rendered":"

O\u00a0Estado de S. Paulo, em 15\/03\/2012<\/em><\/p>\n

\"\"<\/a>Cientistas conseguiram produzir camundongos em laborat\u00f3rio que carregam o sistema imunol\u00f3gico de um ser humano. A t\u00e9cnica poder\u00e1 ser utilizada para testar respostas a imunoterapias, estudar a origem de doen\u00e7as que possuem um componente imunol\u00f3gico e descobrir t\u00e9cnicas para diminuir a rejei\u00e7\u00e3o em transplantes de tecidos.<\/span><\/p>\n

\n
\n

O m\u00e9todo, descrito em artigo na vers\u00e3o digital da revista Science Translational Medicine, \u00e9 vulner\u00e1vel a cr\u00edticas \u00e9ticas, pois utiliza tecido retirado de fetos humanos abortados no quinto m\u00eas de gesta\u00e7\u00e3o e vendidos pela empresa Advanced Biosciences Resource, com sede nos EUA.<\/p>\n

Sob a membrana que reveste o rim dos camundongos, os pesquisadores enxertaram um peda\u00e7o de timo – um \u00f3rg\u00e3o linf\u00e1tico – e de f\u00edgado retirados dos fetos humanos. Seis semanas depois, injetaram na corrente sangu\u00ednea dos animais c\u00e9lulas CD34+ de um ser humano adulto – que teria seu sistema imunol\u00f3gico reproduzido nos animais. As c\u00e9lulas CD34+ colonizaram o tecido transplantado e come\u00e7aram a produzir outras c\u00e9lulas do sistema imune.<\/p>\n

A autora do estudo, Megan Sykes, da Universidade de Columbia, afirma que pretende estudar a diabete tipo 1 no modelo. O m\u00e9dico Jos\u00e9 Xavier Neto, do Laborat\u00f3rio Nacional de Bioci\u00eancias (LNBio), em Campinas, elogiou os resultados do trabalho. Ele explica que o m\u00e9todo n\u00e3o cria linhagens de camundongo transg\u00eanicas, mas produz vers\u00f5es “personalizadas” dos roedores.<\/p>\n

Repercuss\u00e3o:<\/strong> BOL Not\u00edcias<\/a>, UOL Ci\u00eancia e Sa\u00fade<\/a>, VEJA Online<\/a>, Paran\u00e1 Online<\/a>, Jornal de Bras\u00edlia<\/a>, Portal R7<\/a>, Riopretana<\/a><\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

O\u00a0Estado de S. Paulo, em 15\/03\/2012 Cientistas conseguiram produzir camundongos em laborat\u00f3rio que carregam o sistema imunol\u00f3gico de um ser humano. A t\u00e9cnica poder\u00e1 ser utilizada para testar respostas a…<\/p>\n","protected":false},"author":17,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[1163,179],"tags":[1093,1094,1095,1096,1192,242,1097],"class_list":["post-3953","post","type-post","status-publish","format-standard","hentry","category-clipping-cnpem","category-clipping-lnbio","tag-camundongo","tag-genoma","tag-humano","tag-imune","tag-lnbio","tag-recebe","tag-sistema","category-1163","category-179","description-off"],"acf":[],"yoast_head":"\nCamundongo recebe sistema imune humano - CNPEM<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cnpem.br\/camundongo-recebe-sistema-imune-humano\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Camundongo recebe sistema imune humano - CNPEM\" \/>\n<meta property=\"og:description\" content=\"O\u00a0Estado de S. 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