{"id":3621,"date":"2011-11-20T14:28:39","date_gmt":"2011-11-20T16:28:39","guid":{"rendered":"https:\/\/www.cnpem.staging.wpengine.com\/?p=3621"},"modified":"2026-03-03T10:13:29","modified_gmt":"2026-03-03T13:13:29","slug":"pesquisadores-do-lnbio-publicam-artigo-na-nature-chemical-biology","status":"publish","type":"post","link":"https:\/\/cnpem.br\/en\/pesquisadores-do-lnbio-publicam-artigo-na-nature-chemical-biology\/","title":{"rendered":"Pesquisadores do LNBio publicam artigo na Nature Chemical Biology"},"content":{"rendered":"<p style=\"text-align: justify;\"><em>Nature Chemical Biology, em 20 de novembro de 2011<\/em><\/p>\n<p style=\"text-align: justify;\">A edi\u00e7\u00e3o on line da\u00a0<em>Nature Chemical Biology<\/em>, de 20 de novembro, publicou o artigo\u00a0<em>FERM domain interaction with myosin negatively regulates FAK in cardiomyocyte hypertrophy<\/em>, que tem como autores principais Kleber Franchini, diretor do LNBio, e Aline dos Santos, pesquisadora no mesmo laborat\u00f3rio.<\/p>\n<p style=\"text-align: justify;\">O estudo demonstrou a exist\u00eancia de uma intera\u00e7\u00e3o inibit\u00f3ria entre o dom\u00ednio FERM da FAK e miosina sarcom\u00e9rica e apresenta oportunidades potenciais para modular a resposta card\u00edaca hipertr\u00f3fica por meio de mudan\u00e7as na atividade FAK. A FAK regula processos celulares que afetam v\u00e1rios aspectos do desenvolvimento e de doen\u00e7as. O dom\u00ednio FERM da FAK, uma estrutura compacta semelhante a uma roseta, \u00e9 rico em s\u00edtios de intera\u00e7\u00f5es prote\u00edna-prote\u00edna e tamb\u00e9m promove intera\u00e7\u00f5es regulat\u00f3rias intramoleculares. Combinando ensaios de cross-linking acoplados a espectrometria de massas, espalhamento de raios X a baixo \u00e2ngulo no Laborat\u00f3rio Nacional de Luz S\u00edncrotron (LNLS), docking molecular, modelagem de corpo r\u00edgido e an\u00e1lise por muta\u00e7\u00e3o s\u00edtio dirigida, demonstrou-se que uma fenda molecular (~998 \u00c52) no dom\u00ednio FERM da FAK \u00e9 respons\u00e1vel por sua intera\u00e7\u00e3o com a miosina sarcom\u00e9rica, intera\u00e7\u00e3o que resulta na inibi\u00e7\u00e3o da FAK. A miosina controla a tens\u00e3o intracelular.<\/p>\n<p style=\"text-align: justify;\">Muta\u00e7\u00f5es em uma sequ\u00eancia curta de amino\u00e1cidos presentes nesta fenda de intera\u00e7\u00e3o no dom\u00ednio FERM, FP-1, diminu\u00edram a intera\u00e7\u00e3o entre FAK e miosina e aumentaram a atividade da FAK em cardiomi\u00f3citos. Um pept\u00eddeo sint\u00e9tico que mimetiza a seq\u00fc\u00eancia FP-1 inibiu a intera\u00e7\u00e3o com miosina e elevou a atividade da FAK em cardiomi\u00f3citos, promovendo hipertrofia celular por meio da ativa\u00e7\u00e3o da via de sinaliza\u00e7ao AKT-mTOR.<\/p>\n<p style=\"text-align: justify;\"><strong>Acesse o artigo<\/strong>:\u00a0<a href=\"https:\/\/www.nature.com\/nchembio\/journal\/vaop\/ncurrent\/abs\/nchembio.717.html\">https:\/\/www.nature.com\/nchembio\/journal\/vaop\/ncurrent\/abs\/nchembio.717.html<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Nature Chemical Biology, em 20 de novembro de 2011 A edi\u00e7\u00e3o on line da\u00a0Nature Chemical Biology, de 20 de novembro, publicou o artigo\u00a0FERM domain interaction with myosin negatively regulates FAK&hellip;<\/p>\n","protected":false},"author":17,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[1163,179],"tags":[],"class_list":["post-3621","post","type-post","status-publish","format-standard","hentry","category-clipping-cnpem","category-clipping-lnbio","category-1163","category-179","description-off"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.7 - 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