{"id":28294,"date":"2023-01-18T15:22:50","date_gmt":"2023-01-18T18:22:50","guid":{"rendered":"https:\/\/cnpem.br\/capybara-gut-holds-valuable-enzymes-for-biotechnology\/"},"modified":"2023-01-18T15:25:29","modified_gmt":"2023-01-18T18:25:29","slug":"capybara-gut-holds-valuable-enzymes-for-biotechnology","status":"publish","type":"post","link":"https:\/\/cnpem.br\/en\/capybara-gut-holds-valuable-enzymes-for-biotechnology\/","title":{"rendered":"Capybara gut holds valuable enzymes for biotechnology"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column][vc_column_text]<\/p>\n<blockquote>\n<p style=\"text-align: justify;\">Study elucidates unprecedented processes of herbivore metabolism involved in the efficient degradation of plant fibers<\/p>\n<\/blockquote>\n<p style=\"text-align: justify;\">A group of researchers from the Brazilian Biorenewables National Laboratory (LNBR), Brazilian Center for Research in Energy and Materials (CNPEM), an organization supervised by the Brazilian Ministry of Science, Technology and Innovations (MCTI), has published in the journal Nature Communications a study that explores some of the most modern resources of current science to reveal unprecedented and valuable details of the capybara\u2019s digestive process.<\/p>\n<p style=\"text-align: justify;\">The capybara, the largest rodent on the planet, is known for its ability to degrade very efficiently the biomass it consumes, but the details of the animal\u2019s microbiota metabolism that contribute to this characteristic have not yet been elucidated. Researcher Mario Murakami recalls that, in Brazil, this animal is used to eating sugarcane. \u201cSince Brazilian biodiversity is an invaluable source of biotechnological solutions, our hypothesis was that the microorganisms inhabiting capybaras\u2019 intestines have, throughout evolution, developed highly effective molecular strategies for the degradation and use of this biomass of great industrial and economic importance. And that was demonstrated in our study.\u201d<\/p>\n<h3 style=\"text-align: justify;\">\u201cPopulation and molecular inventory\u201d of the gut microbiome<\/h3>\n<p style=\"text-align: justify;\">The meticulous and unprecedented work started with a complete survey of the bacteria present in the capybara\u2019s intestine, in addition to the expressed genes and metabolites produced from plant fibers. To understand the processes of depolymerization of lignocellulosic fibers and the efficient transformation of sugars into energy, a vast combination of techniques, methodologies and resources, including synchrotron light at the MX2 and SAXS1 beamlines of the Brazilian Synchrotron Light Laboratory (LNLS), was required, from the population scale of microorganisms to the atomic and molecular level of enzymes.<\/p>\n<h3 style=\"text-align: justify;\">Discovery<\/h3>\n<p style=\"text-align: justify;\">The elucidation of the entire digestive process of the capybara, by mapping the main metabolic pathways and exploring what is called \u201cgenomic dark matter\u201d, revealed new microorganisms and two new families of enzymes, with potential use in biotechnological applications.<\/p>\n<p style=\"text-align: justify;\">One of the new protein families, named CBM89, is related to the recognition of carbohydrates abundant in grasses such as sugarcane. The second new family of proteins, named GH173, showed promise for applications in the food.<\/p>\n<p style=\"text-align: justify;\">\u201cThe first family proteins have the potential to be tested in enzymatic cocktails used in industrial processes for the manufacture of biofuels, biochemicals and biomaterials. Those from the second family can be tested in processes of metabolizing milk derivatives, to break down lactose, for example\u201d, explains researcher Gabriela Persinoti.<\/p>\n<p style=\"text-align: justify;\">According to researcher Mariana Morais, the novelty of the work leaves another important legacy for the deepening of research on Brazilian biodiversity: \u201cAs the approach was successful, this entire methodology can be useful for studying microbiomes from other sources of Brazilian biodiversity in depth.\u201d<\/p>\n<h3 style=\"text-align: justify;\">Next steps<\/h3>\n<p style=\"text-align: justify;\">As these are new families of proteins, the next steps are related to the expansion of knowledge about the functions and activities of each one of them.<\/p>\n<p style=\"text-align: justify;\">In order to better assess the biotechnological potential, the next stage of the research foresees the use of Sirius\u2019 research stations, the latest generation synchrotron light source designed and operated by CNPEM, in addition to the application of knowledge in the areas of synthetic biology and bioinformatics.<\/p>\n<p style=\"text-align: justify;\"><strong>Source<\/strong>: Cabral, L., Persinoti, G.F., Paix\u00e3o, D.A.A. et al. Gut microbiome of the largest living rodent harbors unprecedented enzymatic systems to degrade plant polysaccharides. Nat Commun 13, 629 (2022). DOI: 10.1038\/s41467-022-28310-y<\/p>\n<p>[\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][vc_column_text] Study elucidates unprecedented processes of herbivore metabolism involved in the efficient degradation of plant fibers A group of researchers from the Brazilian Biorenewables National Laboratory (LNBR), Brazilian Center for&hellip;<\/p>\n","protected":false},"author":17,"featured_media":27784,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[3],"tags":[],"class_list":["post-28294","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized-en","category-3","description-off"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Capybara gut holds valuable enzymes for biotechnology - CNPEM<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cnpem.br\/en\/capybara-gut-holds-valuable-enzymes-for-biotechnology\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Capybara gut holds valuable enzymes for biotechnology - CNPEM\" \/>\n<meta property=\"og:description\" content=\"[vc_row][vc_column][vc_column_text] Study elucidates unprecedented processes of herbivore metabolism involved in the efficient degradation of plant fibers A group of researchers from the Brazilian Biorenewables National Laboratory (LNBR), Brazilian Center for&hellip;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/cnpem.br\/en\/capybara-gut-holds-valuable-enzymes-for-biotechnology\/\" \/>\n<meta property=\"og:site_name\" content=\"CNPEM\" \/>\n<meta property=\"article:published_time\" content=\"2023-01-18T18:22:50+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-01-18T18:25:29+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/cnpem.br\/wp-content\/uploads\/2022\/02\/brian-mcgowan-P1-6ioOcGNU-unsplash-scaled.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2560\" \/>\n\t<meta property=\"og:image:height\" content=\"1707\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Erik Medina\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Erik Medina\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/cnpem.br\\\/en\\\/capybara-gut-holds-valuable-enzymes-for-biotechnology\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/cnpem.br\\\/en\\\/capybara-gut-holds-valuable-enzymes-for-biotechnology\\\/\"},\"author\":{\"name\":\"Erik Medina\",\"@id\":\"https:\\\/\\\/cnpem.br\\\/#\\\/schema\\\/person\\\/b957a8048be4b70d687484cae6b978ef\"},\"headline\":\"Capybara gut holds valuable enzymes for biotechnology\",\"datePublished\":\"2023-01-18T18:22:50+00:00\",\"dateModified\":\"2023-01-18T18:25:29+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/cnpem.br\\\/en\\\/capybara-gut-holds-valuable-enzymes-for-biotechnology\\\/\"},\"wordCount\":579,\"image\":{\"@id\":\"https:\\\/\\\/cnpem.br\\\/en\\\/capybara-gut-holds-valuable-enzymes-for-biotechnology\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/cnpem.br\\\/wp-content\\\/uploads\\\/2022\\\/02\\\/brian-mcgowan-P1-6ioOcGNU-unsplash-scaled.jpg\",\"articleSection\":[\"Uncategorized @en\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/cnpem.br\\\/en\\\/capybara-gut-holds-valuable-enzymes-for-biotechnology\\\/\",\"url\":\"https:\\\/\\\/cnpem.br\\\/en\\\/capybara-gut-holds-valuable-enzymes-for-biotechnology\\\/\",\"name\":\"Capybara gut holds valuable enzymes for biotechnology - CNPEM\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/cnpem.br\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/cnpem.br\\\/en\\\/capybara-gut-holds-valuable-enzymes-for-biotechnology\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/cnpem.br\\\/en\\\/capybara-gut-holds-valuable-enzymes-for-biotechnology\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/cnpem.br\\\/wp-content\\\/uploads\\\/2022\\\/02\\\/brian-mcgowan-P1-6ioOcGNU-unsplash-scaled.jpg\",\"datePublished\":\"2023-01-18T18:22:50+00:00\",\"dateModified\":\"2023-01-18T18:25:29+00:00\",\"author\":{\"@id\":\"https:\\\/\\\/cnpem.br\\\/#\\\/schema\\\/person\\\/b957a8048be4b70d687484cae6b978ef\"},\"breadcrumb\":{\"@id\":\"https:\\\/\\\/cnpem.br\\\/en\\\/capybara-gut-holds-valuable-enzymes-for-biotechnology\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/cnpem.br\\\/en\\\/capybara-gut-holds-valuable-enzymes-for-biotechnology\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/cnpem.br\\\/en\\\/capybara-gut-holds-valuable-enzymes-for-biotechnology\\\/#primaryimage\",\"url\":\"https:\\\/\\\/cnpem.br\\\/wp-content\\\/uploads\\\/2022\\\/02\\\/brian-mcgowan-P1-6ioOcGNU-unsplash-scaled.jpg\",\"contentUrl\":\"https:\\\/\\\/cnpem.br\\\/wp-content\\\/uploads\\\/2022\\\/02\\\/brian-mcgowan-P1-6ioOcGNU-unsplash-scaled.jpg\",\"width\":2560,\"height\":1707},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/cnpem.br\\\/en\\\/capybara-gut-holds-valuable-enzymes-for-biotechnology\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"In\u00edcio\",\"item\":\"https:\\\/\\\/cnpem.br\\\/en\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Capybara gut holds valuable enzymes for biotechnology\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/cnpem.br\\\/#website\",\"url\":\"https:\\\/\\\/cnpem.br\\\/\",\"name\":\"Centro Nacional de Pesquisa em Energia e Materiais\",\"description\":\"Centro Nacional de Pesquisa em Energia e Materiais\",\"alternateName\":\"CNPEM\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/cnpem.br\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/cnpem.br\\\/#\\\/schema\\\/person\\\/b957a8048be4b70d687484cae6b978ef\",\"name\":\"Erik Medina\",\"url\":\"\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Capybara gut holds valuable enzymes for biotechnology - CNPEM","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/cnpem.br\/en\/capybara-gut-holds-valuable-enzymes-for-biotechnology\/","og_locale":"en_US","og_type":"article","og_title":"Capybara gut holds valuable enzymes for biotechnology - CNPEM","og_description":"[vc_row][vc_column][vc_column_text] Study elucidates unprecedented processes of herbivore metabolism involved in the efficient degradation of plant fibers A group of researchers from the Brazilian Biorenewables National Laboratory (LNBR), Brazilian Center for&hellip;","og_url":"https:\/\/cnpem.br\/en\/capybara-gut-holds-valuable-enzymes-for-biotechnology\/","og_site_name":"CNPEM","article_published_time":"2023-01-18T18:22:50+00:00","article_modified_time":"2023-01-18T18:25:29+00:00","og_image":[{"width":2560,"height":1707,"url":"https:\/\/cnpem.br\/wp-content\/uploads\/2022\/02\/brian-mcgowan-P1-6ioOcGNU-unsplash-scaled.jpg","type":"image\/jpeg"}],"author":"Erik Medina","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Erik Medina","Est. reading time":"4 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/cnpem.br\/en\/capybara-gut-holds-valuable-enzymes-for-biotechnology\/#article","isPartOf":{"@id":"https:\/\/cnpem.br\/en\/capybara-gut-holds-valuable-enzymes-for-biotechnology\/"},"author":{"name":"Erik Medina","@id":"https:\/\/cnpem.br\/#\/schema\/person\/b957a8048be4b70d687484cae6b978ef"},"headline":"Capybara gut holds valuable enzymes for biotechnology","datePublished":"2023-01-18T18:22:50+00:00","dateModified":"2023-01-18T18:25:29+00:00","mainEntityOfPage":{"@id":"https:\/\/cnpem.br\/en\/capybara-gut-holds-valuable-enzymes-for-biotechnology\/"},"wordCount":579,"image":{"@id":"https:\/\/cnpem.br\/en\/capybara-gut-holds-valuable-enzymes-for-biotechnology\/#primaryimage"},"thumbnailUrl":"https:\/\/cnpem.br\/wp-content\/uploads\/2022\/02\/brian-mcgowan-P1-6ioOcGNU-unsplash-scaled.jpg","articleSection":["Uncategorized @en"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/cnpem.br\/en\/capybara-gut-holds-valuable-enzymes-for-biotechnology\/","url":"https:\/\/cnpem.br\/en\/capybara-gut-holds-valuable-enzymes-for-biotechnology\/","name":"Capybara gut holds valuable enzymes for biotechnology - CNPEM","isPartOf":{"@id":"https:\/\/cnpem.br\/#website"},"primaryImageOfPage":{"@id":"https:\/\/cnpem.br\/en\/capybara-gut-holds-valuable-enzymes-for-biotechnology\/#primaryimage"},"image":{"@id":"https:\/\/cnpem.br\/en\/capybara-gut-holds-valuable-enzymes-for-biotechnology\/#primaryimage"},"thumbnailUrl":"https:\/\/cnpem.br\/wp-content\/uploads\/2022\/02\/brian-mcgowan-P1-6ioOcGNU-unsplash-scaled.jpg","datePublished":"2023-01-18T18:22:50+00:00","dateModified":"2023-01-18T18:25:29+00:00","author":{"@id":"https:\/\/cnpem.br\/#\/schema\/person\/b957a8048be4b70d687484cae6b978ef"},"breadcrumb":{"@id":"https:\/\/cnpem.br\/en\/capybara-gut-holds-valuable-enzymes-for-biotechnology\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/cnpem.br\/en\/capybara-gut-holds-valuable-enzymes-for-biotechnology\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/cnpem.br\/en\/capybara-gut-holds-valuable-enzymes-for-biotechnology\/#primaryimage","url":"https:\/\/cnpem.br\/wp-content\/uploads\/2022\/02\/brian-mcgowan-P1-6ioOcGNU-unsplash-scaled.jpg","contentUrl":"https:\/\/cnpem.br\/wp-content\/uploads\/2022\/02\/brian-mcgowan-P1-6ioOcGNU-unsplash-scaled.jpg","width":2560,"height":1707},{"@type":"BreadcrumbList","@id":"https:\/\/cnpem.br\/en\/capybara-gut-holds-valuable-enzymes-for-biotechnology\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"In\u00edcio","item":"https:\/\/cnpem.br\/en\/"},{"@type":"ListItem","position":2,"name":"Capybara gut holds valuable enzymes for biotechnology"}]},{"@type":"WebSite","@id":"https:\/\/cnpem.br\/#website","url":"https:\/\/cnpem.br\/","name":"Centro Nacional de Pesquisa em Energia e Materiais","description":"Centro Nacional de Pesquisa em Energia e Materiais","alternateName":"CNPEM","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/cnpem.br\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/cnpem.br\/#\/schema\/person\/b957a8048be4b70d687484cae6b978ef","name":"Erik Medina","url":""}]}},"jetpack_featured_media_url":"https:\/\/cnpem.br\/wp-content\/uploads\/2022\/02\/brian-mcgowan-P1-6ioOcGNU-unsplash-scaled.jpg","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/per0Mi-7mm","_links":{"self":[{"href":"https:\/\/cnpem.br\/en\/wp-json\/wp\/v2\/posts\/28294","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cnpem.br\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cnpem.br\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cnpem.br\/en\/wp-json\/wp\/v2\/users\/17"}],"replies":[{"embeddable":true,"href":"https:\/\/cnpem.br\/en\/wp-json\/wp\/v2\/comments?post=28294"}],"version-history":[{"count":0,"href":"https:\/\/cnpem.br\/en\/wp-json\/wp\/v2\/posts\/28294\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cnpem.br\/en\/wp-json\/wp\/v2\/media\/27784"}],"wp:attachment":[{"href":"https:\/\/cnpem.br\/en\/wp-json\/wp\/v2\/media?parent=28294"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cnpem.br\/en\/wp-json\/wp\/v2\/categories?post=28294"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cnpem.br\/en\/wp-json\/wp\/v2\/tags?post=28294"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}