{"id":65836,"date":"2025-04-04T15:51:13","date_gmt":"2025-04-04T18:51:13","guid":{"rendered":"https:\/\/cnpem.br\/project\/enzimas-alta-performance-quimica-renovavel\/"},"modified":"2026-07-31T16:55:08","modified_gmt":"2026-07-31T19:55:08","slug":"enzimas-alta-performance-quimica-renovavel","status":"publish","type":"dt_portfolio","link":"https:\/\/cnpem.br\/en\/project\/enzimas-alta-performance-quimica-renovavel\/","title":{"rendered":"3-HP: enzimas de alta performance para a ind\u00fastria qu\u00edmica renov\u00e1vel"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column width=&#8221;3\/4&#8243;][vc_custom_heading text=&#8221;Desafio&#8221; google_fonts=&#8221;font_family:Yeseva%20One%3Aregular|font_style:400%20regular%3A400%3Anormal&#8221;][vc_column_text css=&#8221;&#8221;]<\/p>\n<p style=\"text-align: justify;\">O \u00e1cido 3-hidroxipropi\u00f4nico (3-HP) possui diversas aplica\u00e7\u00f5es na produ\u00e7\u00e3o de derivados qu\u00edmicos de grande relev\u00e2ncia industrial, que s\u00e3o convencionalmente obtidos a partir do refinamento de petr\u00f3leo. Por exemplo, na polimeriza\u00e7\u00e3o de pl\u00e1sticos biodegrad\u00e1veis, como o poli-3-hidroxipropionato [poli(3-HP)]; e na produ\u00e7\u00e3o de \u00e1cido acr\u00edlico, essencial para produ\u00e7\u00e3o de tintas, adesivos e pol\u00edmeros superabsorventes, empregados por exemplo em fraldas descart\u00e1veis e produtos de higiene.<\/p>\n<p style=\"text-align: justify;\">Se a produ\u00e7\u00e3o do 3-HP por vias biotecnol\u00f3gicas a partir de biomassa renov\u00e1vel for alcan\u00e7ada, este bioqu\u00edmico pode desempenhar um papel crucial na transi\u00e7\u00e3o para uma economia de baixo carbono, impulsionando a transi\u00e7\u00e3o verde. No entanto, sua <strong>produ\u00e7\u00e3o biotecnol\u00f3gica ainda enfrenta desafios<\/strong>, incluindo <strong>custos elevados e baixa efici\u00eancia<\/strong>, limitando sua competitividade no mercado.<\/p>\n<p>[\/vc_column_text][vc_custom_heading text=&#8221;Produ\u00e7\u00e3o superior em at\u00e9 dez vezes&#8221; font_container=&#8221;tag:h3|text_align:left|color:%23111111&#8243; google_fonts=&#8221;font_family:Yeseva%20One%3Aregular&#8221; css=&#8221;&#8221;][vc_column_text css=&#8221;&#8221;]<\/p>\n<p style=\"text-align: justify;\">Pesquisadores do CNPEM aplicaram ferramentas de engenharia de prote\u00ednas para desenvolver uma nova enzima malonil-CoA redutase com alta efici\u00eancia em levedura. O resultado? <strong>Um aumento de at\u00e9 dez vezes na produ\u00e7\u00e3o em apenas 48 horas <\/strong>em compara\u00e7\u00e3o com a enzima mais eficaz conhecida atualmente.<\/p>\n<p>[\/vc_column_text][vc_cta h2=&#8221;Diferenciais da tecnologia&#8221; h2_font_container=&#8221;tag:h3|text_align:left|color:%23111111&#8243; h2_google_fonts=&#8221;font_family:Yeseva%20One%3Aregular|font_style:400%20regular%3A400%3Anormal&#8221; add_icon=&#8221;left&#8221; i_icon_fontawesome=&#8221;fas fa-exclamation-circle&#8221; i_color=&#8221;violet&#8221; css=&#8221;&#8221; use_custom_fonts_h2=&#8221;true&#8221;]<\/p>\n<ul>\n<li><strong>Mais produtividade: <\/strong>Aumento expressivo na produ\u00e7\u00e3o de 3-HP sem necessidade de grandes adapta\u00e7\u00f5es industriais;<\/li>\n<li><strong>Sustentabilidade:<\/strong> o <strong>3-HP <\/strong>serve como base para a produ\u00e7\u00e3o de produtos qu\u00edmicos renov\u00e1veis.<\/li>\n<\/ul>\n<p>[\/vc_cta][vc_cta h2=&#8221;Aplica\u00e7\u00f5es&#8221; h2_font_container=&#8221;tag:h3|text_align:left|color:%23111111&#8243; h2_google_fonts=&#8221;font_family:Yeseva%20One%3Aregular|font_style:400%20regular%3A400%3Anormal&#8221; add_icon=&#8221;left&#8221; i_icon_fontawesome=&#8221;fas fa-exclamation-circle&#8221; i_color=&#8221;violet&#8221; css=&#8221;&#8221; use_custom_fonts_h2=&#8221;true&#8221;]<\/p>\n<ul>\n<li><strong>Ind\u00fastria qu\u00edmica:<\/strong> Intermedi\u00e1rio para s\u00edntese de qu\u00edmicos sustent\u00e1veis;<\/li>\n<li><strong>Cosm\u00e9ticos e higiene:<\/strong> Produ\u00e7\u00e3o de \u00e1cido acr\u00edlico para superabsorventes;<\/li>\n<li><strong>Biopl\u00e1sticos: <\/strong>Alternativa renov\u00e1vel de mon\u00f4meros para produ\u00e7\u00e3o de polihidroxialcanoatos (PHAs) utilizados em embalagens e filmes biodegrad\u00e1veis;<\/li>\n<li><strong>Alimentos e bebidas:<\/strong> pode ser utilizado como intermedi\u00e1rio na produ\u00e7\u00e3o de conservantes e antioxidantes;<\/li>\n<li><strong>Espec\u00edfica:<\/strong> a tecnologia pode ser adaptada, suprindo a demanda do seu neg\u00f3cio com o apoio dos pesquisadores do CNPEM. Sujeito a contrata\u00e7\u00f5es adicionais.<\/li>\n<\/ul>\n<p>[\/vc_cta][\/vc_column][vc_column width=&#8221;1\/4&#8243;]<style type=\"text\/css\" data-type=\"the7_shortcodes-inline-css\">.shortcode-single-image-wrap.shortcode-single-image-f5ce0ffcc00e86c68c5b96c16b0dcffe.enable-bg-rollover .rollover i,\n.shortcode-single-image-wrap.shortcode-single-image-f5ce0ffcc00e86c68c5b96c16b0dcffe.enable-bg-rollover .rollover-video i {\n  background: -webkit-linear-gradient();\n  background: linear-gradient();\n}\n.shortcode-single-image-wrap.shortcode-single-image-f5ce0ffcc00e86c68c5b96c16b0dcffe .rollover-icon {\n  font-size: 32px;\n  color: #ffffff;\n  min-width: 44px;\n  min-height: 44px;\n  line-height: 44px;\n  border-radius: 100px;\n  border-style: solid;\n  border-width: 0px;\n}\n.dt-icon-bg-on.shortcode-single-image-wrap.shortcode-single-image-f5ce0ffcc00e86c68c5b96c16b0dcffe .rollover-icon {\n  background: rgba(255,255,255,0.3);\n  box-shadow: none;\n}<\/style><div 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data-dt-location=\"https:\/\/cnpem.br\/en\/project\/enzimas-alta-performance-quimica-renovavel\/3-hp-enzimas-alta-performance\/\" style=\"--ratio: 293 \/ 293;\" alt=\"\" \/><\/div><\/div><\/div>[vc_empty_space height=&#8221;26px&#8221;][\/vc_column][\/vc_row][vc_row][vc_column width=&#8221;1\/3&#8243;][vc_separator color=&#8221;violet&#8221; border_width=&#8221;3&#8243;][vc_custom_heading text=&#8221;Escala de desenvolvimento&#8221; font_container=&#8221;tag:h3|text_align:left&#8221; google_fonts=&#8221;font_family:Yeseva%20One%3Aregular|font_style:400%20regular%3A400%3Anormal&#8221;][vc_column_text css=&#8221;&#8221;]TRL 7<br \/>\nDemonstra\u00e7\u00e3o de prot\u00f3tipo<br \/>\nem ambiente operacional[\/vc_column_text][\/vc_column][vc_column width=&#8221;1\/3&#8243;][vc_separator color=&#8221;violet&#8221; border_width=&#8221;3&#8243;][vc_custom_heading text=&#8221;Propriedade intelectual&#8221; font_container=&#8221;tag:h3|text_align:left&#8221; google_fonts=&#8221;font_family:Yeseva%20One%3Aregular|font_style:400%20regular%3A400%3Anormal&#8221;][vc_column_text css=&#8221;&#8221;]CNPEM<br \/>\nBR 10 2024 026232 8<br \/>\nLeonardo Blankenburg Lins Barroso Arruda | Leticia Maria Zanphorlin Murakami | Nadia Maria Vieira Sampaio[\/vc_column_text][\/vc_column][vc_column width=&#8221;1\/3&#8243;][vc_separator color=&#8221;violet&#8221; border_width=&#8221;3&#8243;][vc_custom_heading text=&#8221;D\u00favidas e licenciamento&#8221; font_container=&#8221;tag:h3|text_align:left&#8221; google_fonts=&#8221;font_family:Yeseva%20One%3Aregular|font_style:400%20regular%3A400%3Anormal&#8221;][vc_column_text css=&#8221;&#8221;]ID da tecnologia: PI183<br \/>\n<a href=\"mailto:inovacao@cnpem.br\">inovacao@cnpem.br<\/a><br \/>\n19 3512-1174[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column width=&#8221;1\/2&#8243;][vc_custom_heading text=&#8221;Objetivos do<br \/>\nDesenvolvimento<br \/>\nSustent\u00e1vel&#8221; 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data-srcset=\"https:\/\/cnpem.br\/wp-content\/uploads\/2022\/04\/13-Acao-contra-a-acao-global-do-clima.-Vetorizada.-PNG.-Com-titulo.-Colorida-500x500.png 500w, https:\/\/cnpem.br\/wp-content\/uploads\/2022\/04\/13-Acao-contra-a-acao-global-do-clima.-Vetorizada.-PNG.-Com-titulo.-Colorida-1000x1000.png 1000w\" loading=\"eager\" sizes=\"(max-width: 500px) 100vw, 500px\" width=\"500\" height=\"500\"  data-dt-location=\"https:\/\/cnpem.br\/en\/project\/dispositivos-biocompativeis\/13-acao-contra-a-acao-global-do-clima-vetorizada-png-com-titulo-colorida\/\" style=\"--ratio: 500 \/ 500;\" alt=\"\" \/><\/div><\/div><\/div>[\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Um salto na produ\u00e7\u00e3o biotecnol\u00f3gica de \u00e1cido 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